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We dont have a definitive answer yet, but heres what we do know: Using GLP-1s for at least 12 months improves outcomes Stopping often leads to weight regain
adherence and sustainability determine long-term success
Quantity (e.g.,1/4 -1 daily) Directions (e.g., Dissolve under the tongue as directed) Optional: Additives like B12 or naltrexone We can assist with customized Rx templates and dosing protocols
In addition to the lack of functional NNT in C57BL/6J mice (Ronchi et al., 2013), they also lack the stop codon for the NADK2 gene, resulting in a longer, potentially unstable mitochondrial protein (Timmermans and Libert, 2018) that may further contribute to the dysfunctional mitochondrial NADPH generation and antioxidant function