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In a pooled analysis of glycemic control trials, patients reported diabetic retinopathy related adverse reactions during the trial (4.2% with semaglutide tablets and 3.8% with comparator)
[10] Pharmacodynamic modeling indicates that exposure-response curves plateau near 20 mg, but the long half-life sustains clinically relevant plasma levels for up to 36 hours, allowing on-demand dosing flexibility and once-daily regimens for chronic indications
Strict sun protection is required post-treatment
doi:10.1007/s12011-011-9289-1
Mild-to-moderate chronic kidney disease is not a contraindication to GLP-1 therapy
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