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[DOI] [PubMed] [Google Scholar] 57.Zhu Y., Xu J., Zhang D., Mu X., Shi Y., Chen S., Wu Z., Li S
When an insurer claims that a clinicians recommended drug or procedure is not medically necessary, or there is another lower-cost option available, the original order can be denied for coverage
It is the same medication, but instead of a weekly injection, it is taken as a once daily tablet
Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)
Care must therefore be taken in weighting the diagnosis too heavily based these findings as well as speed of onset
