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Outside Russia and Ukraine, it is not approved for any clinical use and remains a research compound
207 A recent study introduced new experiment designs using HepatoPac (Hepregen Corporation, Medford, MA, USA), spheroids or liver-on-a-chip models to assess the modulation of CYPs and transporter gene expression by peptides, but further large-scale experiments are still needed
This was notably not due to any new safety concerns and may potentially be driven by the manufacturers reluctance to introduce a black triangle to ensure clinician and patient awareness of the increased monitoring requirements in type 1 diabetes [29]
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Systemic effects of GLP-1 RAs, mediated via GLP-1 receptors in other organs and systems, include enhanced endothelial function and myocardial metabolism, natriuresis and anti-inflammatory and blood pressure-lowering effects
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