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Study of the mutations in VDBP/CYP2R1 genes in humans and Vdbp/Cyp2r1 knockdown mice models showed low levels of 25(OH)VD [14,20]
Genomic instability and DNA damage response (DDR) Genomic instability, which involves damage to DNA and mutations, contributes to the acceleration of aging
Front Nutr 9:1048258 Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Although distinct differences exist between methylcobalamin and cyanocobalamin, both have beneficial effects on health and can prevent B12 deficiencies ( In fact, one study found that treating seven B12-deficient people with oral methylcobalamin normalized vitamin B12 levels in their blood within just 2 months ( Similarly, another study showed that taking cyanocobalamin capsules for 3 months also increased vitamin B12 levels in 10 people with pernicious anemia, a condition caused by impaired B12 absorption ( Both types of the vitamin may also provide other health benefits