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While glutathione is approved for certain medical applications, its use for cosmetic enhancement remains off-label, placing responsibility on providers and patients to navigate potential risks without regulatory guidance

It is human data in one population (people with HIV-associated central fat accumulation) with one endpoint (visceral fat)

Thus, the inability to account for inhibition of IGF-2 binding to the IGF-1R is an important limitation in this study, which should be considered when assessing outcomes from human trials using IGF-1R mAbs

Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-2 28 (Figure 1)

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