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A prescriber typically starts at the lower end of an established range to assess tolerability, then adjusts, where applicable, based on response and side-effect profile

Microb Cell Factories 11:111 Yu Z, Yu H, Xu J, Wang Z, Wang Z, Kang T, Chen K, Pu Z, Wu J, Yang L (2022) Enhancing thermostability of lipase from Pseudomonas alcaligenes for producing l-menthol by the CREATE strategy

Bupropion does not typically cause temperature sensitivity, but the stimulant-like properties can cause sweating in some users, creating a confusing situation where someone feels cold from tirzepatide weight loss but sweats from bupropion norepinephrine activity

Alternatively, consider injectable semaglutide to avoid the absorption conflict entirely

Ard J, Fitch A, Fruh S, Herman L