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EPX040-10825-901, Thermo Fisher Scientific) was used for coagulation factor profiling

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Pediatric Dosing Recommended dosage for children may vary based on different medical conditions: For the initial treatment of pernicious anemia, the usual dose is 30-50mcg SC/IM, given every day for 2 weeks, followed by maintenance treatment

To assess the interaction between human Met and the macrocycles, human Met ectodomain-Fc chimera was immobilized to a surface density of 1,2001,600 response units (RUs) on a CM5 sensor chip using a human antibody capture kit (GE Healthcare)

Researchers raise doses in animals until roughly 50% die, giving a crude measure of acute lethality that does not translate directly to human safety but gives context for risk margins