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As for seasoned smokers, flavored tobaccos offers a delightful change of pace from traditional blends

The need for precise dosing across these formats often results in underdosing or misuse in real-world conditions, limiting quit success rates compared to controlled clinical trials

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To the extent that the mass of tobacco in the cigarette determines nicotine delivery, Vleeming et al.'s [128] approach suggests that the underestimates of toxin exposures the rats received compared to human smokers could be substantial

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