There isnt any published evidence supporting that it is a gut peptide.
If BPC-157 builds the road, TB-500 is the bus that drives the workers to the site
So, the route of administration matters
There are other ways to get that fix of B12

References Cell Metabolism (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance (Lee C, Zeng J, Drew BG, et al.) Journal of Translational Medicine (2023) Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging (Wan W, Zhang L, Lin Y, et al.) Journal of Molecular Medicine (2019) MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction (Lu H, Wei M, Zhai Y, et al.) Nature Communications (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis (Reynolds JC, Lai RW, Woodhead JST, et al.) Frontiers in Physiology (2023) Role of MOTS-c in the regulation of bone metabolism (Yi X, Hu G, Yang Y, et al.) Cognitive Vitality Reports (2021) MOTS-c (Cognitive Vitality Profile) Alzheimers Drug Discovery Foundation (ADDF) USADA Spirit of Sport (2023) What is the MOTS-c peptide