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A place where mitochondrial trouble occurs frequently is the brain [108]

And they deserve to be called what they also are: metabolic correctors

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Augmentation of IGF-I levels in the muscle increases AR clearance through the ubiquitin-proteasome system and AR phosphorylation by Akt[40], and in a mouse model of SBMA, muscle-specific overexpression of IGF-I was able to improve motor performance and body weight [40]