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In-depth mechanistic studies revealed that apoC3 and apoA5 regulated plasma TG levels through multiple pathways
This is mechanistically distinct from the appetite effect and explains why tirzepatide produces greater fat-mass loss relative to lean-mass loss compared to GLP-1 monotherapy in DEXA substudy data from SURPASS-3 [24]
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doi: 10.1083/jcb.152.5.1071
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