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Methods and results The cytotoxic effects of metformin with or without the presence of SBI0206965 (AMPK inhibitor) on LNCaP cells were determined using MTT and trypan blue exclusion assays

The risk of using a topical retinoid is likely much lower, she says, but because the potential effects are so severe, and so little research has been done to understand the topical risks, it's best to err on the side of caution