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The extensive safety data from clinical trials in other applications provides reassurance regarding tolerability
Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models
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At the same time, we noticed, that SHBG does not affect the morphological architecture of EqASCEMS growth pattern which correlates with our previous findings in which we demonstrated that the exogenous SHBG treatment enhanced the proliferation, cell cycle progression, and survival of ASCs, while concurrently decreasing the expression of p53 and p21 , which are known as pro-apoptotic mediators [34]
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